If you cannot clean up computers from the console, you can perform the cleanup manually.
In the computer list, double-click the infected computer.
In the Computer details dialog box, scroll down to the Outstanding alerts and
errors section. In the list of detected items, click the name of the item you want
to remove from the computer.
This connects you to the Sophos website, where you can read advice on how to clean up the computer.
Go to the computer and carry out the cleanup manually.
Note: The Sophos website provides special downloadable disinfectors for certain viruses and worms.